癌細胞擴散至距離原始腫瘤遙遠的器官及組織。此時癌細胞流竄於全身，必需借助循環全身的化學治療藥物治療。安寧照護將是治療選項之一。全身性的症狀：體重減輕、食欲不振、惡病體質、大量出汗（夜間盜汗）、貧血神經膠質瘤：由神經膠質細胞變化成腫瘤�

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